Carnosine: The amazing anti-aging nutrient

Carnosine: The amazing anti-aging nutrient

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is a small peptide that contains two amino acids,

beta- alanine and histidine. It is found in

high concentrations in skeletal muscles, cardiac muscle

supplements have been popular among body-builders

and athletes mainly for improving muscular fatigue.

Now, based on over 800 studies, it''s being viewed

as one of the most important supplements for longevity

based on its amazing properties. It is also a neuroprotectant,

a modulator of enzyme activities, and a chelator of

carnosine''s other benefits have not been extensively

researched, based on preliminary studies done in Russia,

it has also been shown to be beneficial for its ability

promote wound healing, protect against radiation damage

animals treated with carnosine were found to have

faster and better wound healing rates compared to

controls. This has potential applications to treating

burns, wounds following surgery, or during nutritional

protect against the formation of gastric ulcers, and

help eradicate Helicobacter pylori, an organism

that has been linked to peptic ulcer and stomach cancer

reduce or completely prevent cell damage caused by

beta amyloid 12, the substance found in

the brain of Alzheimer''s disease patients

protect against the effect of glucose damage and protein

inhibit (or reverse) glycosylation and therefore slow

the damaging – and pro-aging – effects of carbohydrate

sources of carnosine incude meat, poultry and fish,

but with the decrease in meat consumption, many people

are getting less and less carnosine in their diet.

But even if you do eat meat, as we naturally

age, carnosine levels are reduced. This reduction

in muscle carnosine concentration may be one of the

causes of the decline in muscle mass, strength and

is a high concentration of carnosine found in actively

contracting muscles, and a low concentration found

in weakened muscles, such as those affected by muscular

dystrophy. In fact, people who suffer from a neuromuscular

disease exhibit a 63% decline of muscle concentrations

of carnosine, from the years 10 to 70.13

and trauma also contribute to a reduction in carnosine

levels, which may be a factor in the increased mortality

rate in the elderly following stressful events.14All the more reason to take a carnosine nutritional

a potent antioxidant, carnosine stabilizes and protects

the cell membrane by quenching the most destructive

of free radicals— the hydroxyl radical—as well as

the superoxide, singlet oxygen and the peroxyl radical.

prevents lipid peroxidation within the cell membrane,

and is believed to be the water-soluble counterpart

to vitamin E in protecting cell membranes from oxidative

damage.15 During the process of lipid peroxidation,

lipids (such as the phospholipids in cell membranes

and fatty acids in the bloodstream) are subject to

attack by free radicals, which damage them by oxidation.

has specifically been shown to block a highly reactive

end product of lipid peroxidation called malondialdegyde

(MDA). 16, 17 If left unchecked, MDA can

cause damage to lipids, enzymes and DNA, and contribute

to atherosclerosis, joint inflammation, cataract formation,

does carnosine work as an anti-aging nutrient?Proteins

are the substances most responsible for the daily

functioning of living organisms. When proteins are

damaged and modified—due to a variety of complex chemical

linking,20 and the production of AGEs (advanced

is a dramatic impact on the functioning and appearance

of the body. Our faces begin to sag and wither, our

energy levels decrease, and without our even realizing

it, all of a sudden we look differently than we did

to Karin Granstrom Jordan, M.D. ("Carnosine: Nature''s

pluripotent life extension agent" Life Extension

as we age, while carnosine levels are declining. Once

a protein is modified it has lost its ability to function

normally, and when a significant portion of the body''s

protein has reached this point, the body becomes more

prone to degenerative diseases." Carnosine is now

believed to bind and modify damaged proteins in a

vital process that helps our cells properly target

good news is that carnosine has emerged as the

most promising broad spectrum shield against

improved facial appearance, muscular stamina and general

a preliminary anti-aging experiment, Marios Kyriazis

MD gave carnosine supplements (50 mg. daily)

to 20 healthy human volunteers, aged 40 - 75 years,

for a period of 1-4 months. No side effects were reported.

Five users noticed significant improvements in their

facial appearance (firmer facial muscles), muscular

stamina and general well being. Five others reported

possible benefits, for example better sleep patterns,

improved clarity of thought and increased libido.

The rest did not report any noticeable effects.

this study evokes optimism, we should note that it

was only a preliminary study, was not placebo controlled

and relied on the participant’s subjective reports.

Kyriazis reported that it is not surprising that some

of the volunteers did not report any noticeable effects

because "supplementation with carnosine is not expected

to show any significant noticeable benefits in a short

time, but it should be used as an insurance against

deleterious effects of the aging process. If any benefits

are noted, these should be considered as an added

extra bonus. It is worthwhile persevering with

the carnosine supplementation long term, even if you

do not experience any obvious benefits, as you will

still be well protected against aging."

one study done on laboratory animals, carnosine was

shown to slow the development of aging in "senescence-accelerated"

animals (animals bred for rapid aging) when added

to their diet. These effects were seen not only on

lifespan, but also on behavioral changes and physical

deterioration. Carnosine also had a similar though

smaller effect on normal, long-lived animals not chosen

for their rapid aging features, making it an interesting

supplement for those of us worried about premature

you want to try a safe and effective anti-aging supplement,

you can''t go wrong with carnosine. Carnosine offers

potent protection against free radicals and protein

modification by itself. For added protection, take

it along with vitamin E and/or Co-enzyme Q10.

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properties, functions and potential therapeutic applications.

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carnosine and its components on free-radical reactions.

Hipkiss AR, Preston JE, Himsworth DT. Pluripotent

protective effects of carnosine, a naturally occurring

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Lee JW, Miyawaki H, Bobst EV, et al. Improved functional

recovery of ischemic rat hearts due to singlet oxygen

scavengers histidine and carnosine. J Mol Cell

Ilipkiss A. et al. Protective effects of carnosine

against protein modification mediated by nialondialdchyde

Nishiwaki H, Kato S, Sugamoto S, et al. Ulcerogenic

and healing impairing actions of monochloramine in

rat stomachs: effects of zinc L-carnosine, polaprezinc.

Arakawa T, Satoh H, Nakamura A, et al. Effects of

zinc L-carnosine on gastric mucosal and cell damage

caused by ethanol in rats. Correlation with endogenous

Kashimura H, Suzuki K, Hassan M, et al. Polaprezinc,

a mucosal protective agent, in combination with lansoprazole,

amoxycillin and clarithromycin increases the cure

rate of Helicobacter pylori infection. Aliment

J et al. Toxic effects of B-amyloid on immortalized

rat brain endothelial cell: protection by carnosine,

Stuerenburg HJ, Kunze K; Concentrations of free carnosine

(a putative membrane-protective antioxidant) in human

muscle Biopsies and rat muscles. Archives of Gerontology

Tarnha M, et al. Hydroxyl radical scavenging by carnosine

and Cu(ii)-carm)sine complexes. Int J Radial Biol,

Hipkiss A. et al. Protective effects of carnosine

against MDA-induced toxicity towards cultured rat

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against protein modification mediated by nialondialdchyde

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Berlett BS, Stadtman ER. Protein oxidation in aging,

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Bierhaus A, Hofmann MA, Ziegler R, et al. AGEs and

their interaction with AGE-receptors in vascular disease

and diabetes mellitus. I. The AGE concept. Cardiovascular

Munch G, Schinzel R, Loske C, et al. Alzheimer''s disease--synergistic

effects of glucose deficit, oxidative stress and advanced

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Ilipkiss A, Ghana 14. Carnosine protects proteins

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